Food and levothyroxine administration in infants and children.

Administer tablets and capsules with water on an empty stomach, preferably one-half hour to an hour before breakfast. Administer four hours apart from antacids, iron, and calcium supplements (Prod Info Tirosint oral capsules, 2006; Prod Info Synthroid oral tablets, 2005; Prod Info Levoxyl oral tablets, 2004). Levothyroxine tablets may be crushed and suspended in 5 to 10 milliliters of water prior to administration. The suspension should be given immediately by a spoon or dropper. The crushed tablet may also be sprinkled over a small amount of food (applesauce or cooked cereal). Foods containing large amounts of soybean, fiber, or iron should not be used for administering levothyroxine (Prod Info Synthroid oral tablets, 2005).